Filaggrin Mutation in Korean Patients with Atopic Dermatitis.

ABSTRACT:

Purpose

Atopic dermatitis (AD) is a chronic, relapsing eczematous inflammatory skin disease. Mutations in the filaggrin gene (FLG) are major predisposing factors for AD. Ethnic differences exist between Asian and European populations in the frequency and spectrum of FLG mutations. Moreover, a distinct set of FLG mutations has been reported in Asian populations. The aim of this study was to examine the spectrum of FLG mutations in Koreans with AD. We also investigated the association of FLG mutations and clinical features of AD and compared the Korean FLG landscape with that of other East Asian countries.

Materials and methods

Seventy Korean patients with AD were enrolled in this study. Fourteen FLG mutations previously detected in Korean, Japanese, and Chinese patients were

SUBMITTER: On HR 

PROVIDER: S-EPMC5290020 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature