Adipose tissue metabolic and inflammatory responses to a mixed meal in lean, overweight and obese men.

ABSTRACT:

Purpose

Most of what we know about adipose tissue is restricted to observations derived after an overnight fast. However, humans spend the majority of waking hours in a postprandial (fed) state, and it is unclear whether increasing adiposity impacts adipose tissue responses to feeding. The aim of this research was to investigate postprandial responses in adipose tissue across varying degrees of adiposity.

Methods

Thirty males aged 35-55 years with waist circumference 81-118 cm were divided equally into groups categorized as either lean, overweight or obese. Participants consumed a meal and insulinaemic, glycaemic and lipidaemic responses were monitored over 6 h. Subcutaneous adipose tissue samples were obtained at baseline and after 6 h to examine changes in gene expression

SUBMITTER: Travers RL 

PROVIDER: S-EPMC5290042 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature