Early-life exposures to persistent organic pollutants in relation to overweight in preschool children.

ABSTRACT: Current knowledge on obesogenic effects of persistent organic pollutants (POPs) is equivocal. We therefore evaluated the associations between early-life POP exposures and body mass index (BMI) in 444 Faroese children born in 2007-2009. POPs were measured in maternal 2-week postpartum serum and child age-5 serum. Linear regression and generalised linear models assessed the associations with continuous and dichotomous BMI z-scores, respectively, at ages 18 months and/or 5 years. Maternal serum concentrations of HCB, PFOS and PFOA were associated with increased BMI z-scores and/or overweight risk (i.e. BMI z-score≥85th WHO percentile). No clear association was found for maternal serum-PCBs, p,p'-DDE, PFHxS, PFNA and PFDA. In cross-sectional analyses, we observed a pattern of inverse associati

SUBMITTER: Karlsen M 

PROVIDER: S-EPMC5290287 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature