Peripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid.

ABSTRACT: The blood-brain barrier separates circulating blood from the central nervous system (CNS). The scope of this barrier is not fully understood which limits our ability to relate biological measurements from peripheral to central phenotypes. For example, it is unknown to what extent gene expression levels in peripheral blood are reflective of CNS metabolism. In this study, we examine links between central monoamine metabolite levels and whole-blood gene expression to better understand the connection between peripheral systems and the CNS. To that end, we correlated the prime monoamine metabolites in cerebrospinal fluid (CSF) with whole-genome gene expression microarray data from blood (N=240 human subjects). We additionally applied gene-enrichment analysis and weighted gene co-expression netw

SUBMITTER: Luykx JJ 

PROVIDER: S-EPMC5290339 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature