Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions.

ABSTRACT: Differences in general cognitive function have been shown to be partly heritable and to show genetic correlations with several psychiatric and physical disease states. However, to date, few single-nucleotide polymorphisms (SNPs) have demonstrated genome-wide significance, hampering efforts aimed at determining which genetic variants are most important for cognitive function and which regions drive the genetic associations between cognitive function and disease states. Here, we combine multiple large genome-wide association study (GWAS) data sets, from the CHARGE cognitive consortium (n=53 949) and UK Biobank (n=36 035), to partition the genome into 52 functional annotations and an additional 10 annotations describing tissue-specific histone marks. Using stratified linkage disequilibrium sc

SUBMITTER: Hill WD 

PROVIDER: S-EPMC5290340 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature