Implication of NOTCH1 gene in susceptibility to anxiety and depression among sexual abuse victims.

ABSTRACT: Sexual abuse contributes to the development of multiple forms of psychopathology, including anxiety and depression, but the extent to which genetics contributes to these disorders among sexual abuse victims remains unclear. In this translational study, we first examined gene expression in the brains of rodents exposed to different early-life conditions (long, brief or no maternal separation). Hypothesizing that genes revealing changes in expression may have relevance for psychiatric symptoms later in life, we examined possible association of those genes with symptoms of anxiety and depression in a human sample of sexual abuse victims. Changes in rodent brain gene expression were evaluated by means of correspondence and significance analyses of microarrays by comparing brains of rodents exp

SUBMITTER: Steine IM 

PROVIDER: S-EPMC5290341 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature