Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines.

ABSTRACT: Propionic acid (PPA) is a ubiquitous short-chain fatty acid, which is a major fermentation product of the enteric microbiome. PPA is a normal intermediate of metabolism and is found in foods, either naturally or as a preservative. PPA and its derivatives have been implicated in both health and disease. Whereas PPA is an energy substrate and has many proposed beneficial effects, it is also associated with human disorders involving mitochondrial dysfunction, including propionic acidemia and autism spectrum disorders (ASDs). We aimed to investigate the dichotomy between the health and disease effects of PPA by measuring mitochondrial function in ASD and age- and gender-matched control lymphoblastoid cell lines (LCLs) following incubation with PPA at several concentrations and durations both w

SUBMITTER: Frye RE 

PROVIDER: S-EPMC5290345 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature