Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study.

ABSTRACT:

Background and purpose

Stroke is a multifactorial disease influenced by both genetic and environmental factors. The aim of this case-control study was to determine the association between β-fibrinogen C148T (rs1800787) gene polymorphism and susceptibility to ischemic stroke (IS) in a North Indian population.

Methods

In the present case-control study, genotyping was performed using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method on 250 IS patients and 250 age- and sex-matched controls. Frequency distributions of genotypes and alleles were compared between the cases and controls by conditional logistic regression.

Results

Hypertension, diabetes, dyslipidemia, low socioeconomic status, and family history of stroke were found to be

SUBMITTER: Kumar A 

PROVIDER: S-EPMC5290428 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature