Self-assemble nanoparticles based on polypeptides containing C-terminal luminescent Pt-cysteine complex.

ABSTRACT: The growing attention to the luminescent nanocarriers is strongly stimulated by their potential application as drug delivery systems and by the necessity to monitor their distribution in cells and tissues. In this communication we report on the synthesis of amphiphilic polypeptides bearing C-terminal phosphorescent label together with preparation of nanoparticles using the polypeptides obtained. The approach suggested is based on a unique and highly technological process where the new phosphorescent Pt-cysteine complex serves as initiator of the ring-opening polymerization of α-amino acid N-carboxyanhydrides to obtain the polypeptides bearing intact the platinum chromophore covalently bound to the polymer chain. It was established that the luminescent label retains unchanged its emission c

SUBMITTER: Vlakh EG 

PROVIDER: S-EPMC5290470 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature