Role of vitamin A metabolism in IIH: Results from the idiopathic intracranial hypertension treatment trial.

ABSTRACT:

Introduction

Vitamin A and its metabolites (called retinoids) have been thought to play a role in the development of idiopathic intracranial hypertension (IIH). The IIH Treatment Trial (IIHTT) showed the efficacy of acetazolamide (ACZ) in improving visual field function, papilledema grade, quality of life and cerebrospinal fluid (CSF) pressure. We postulated that IIH patients would demonstrate elevated measures of vitamin A metabolites in the serum and CSF.

Methods

Comprehensive measures of serum vitamin A and its metabolites were obtained from 96 IIHTT subjects, randomly assigned to treatment with ACZ or placebo, and 25 controls with similar gender, age and body mass index (BMI). These included retinol, retinol binding protein, all-trans retinoic acid (ATRA), alpha- and bet

SUBMITTER: Libien J 

PROVIDER: S-EPMC5290478 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature