Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders.

ABSTRACT: The title nitro-pyrrole-based compounds, C₇H₈N₂O₄, (I) (ethyl 4-nitro-1H-pyrrole-2-carboxyl-ate), its derivative C₁₂H₁₄N₂O₄, (II) [ethyl 4-nitro-1-(4-pent-yn-yl)-1H-pyrrole-2-carboxyl-ate], C₁₅H₂₆N₄O₃, (III) {N-[3-(di-methyamino)prop-yl]-1-isopentyl-4-nitro-1H-pyrrole-2-carboxamide}, and C₂₀H₂₇N₉O₅, (IV) {1-(3-azido-prop-yl)-4-(1-methyl-4-nitro-1H-pyrrole-2-carboxamido)-N-[2-(morpholin-4-yl)eth-yl]-1H-pyrrole-2-carboxamide}, are inter-mediates used in the synthesis of modified DNA minor-groove binders. In all four compounds, the nitro groups lie in the plane of the pyr

SUBMITTER: Kennedy AR 

PROVIDER: S-EPMC5290577 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature