UGT74S1 is the key player in controlling secoisolariciresinol diglucoside (SDG) formation in flax.

ABSTRACT:

Background

Flax lignan, commonly known as secoisolariciresinol (SECO) diglucoside (SDG), has recently been reported with health-promoting activities, including its positive impact in metabolic diseases. However, not much was reported on the biosynthesis of SDG and its monoglucoside (SMG) until lately. Flax UGT74S1 was recently reported to sequentially glucosylate SECO into SMG and SDG in vitro. However, whether this gene is the only UGT achieving SECO glucosylation in flax was not known.

Results

Flax genome-wide mining for UGTs was performed. Phylogenetic and gene duplication analyses, heterologous gene expression and enzyme assays were conducted to identify family members closely related to UGT74S1 and to establish their roles in SECO glucosylation. A total of 299 different

SUBMITTER: Fofana B 

PROVIDER: S-EPMC5290659 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature