Using Domestic and Free-Ranging Arctic Canid Models for Environmental Molecular Toxicology Research.

ABSTRACT: The use of sentinel species for population and ecosystem health assessments has been advocated as part of a One Health perspective. The Arctic is experiencing rapid change, including climate and environmental shifts, as well as increased resource development, which will alter exposure of biota to environmental agents of disease. Arctic canid species have wide geographic ranges and feeding ecologies and are often exposed to high concentrations of both terrestrial and marine-based contaminants. The domestic dog (Canis lupus familiaris) has been used in biomedical research for a number of years and has been advocated as a sentinel for human health due to its proximity to humans and, in some instances, similar diet. Exploiting the potential of molecular tools for describing the toxicogenomics

SUBMITTER: Harley JR 

PROVIDER: S-EPMC5290708 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature