Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action.

ABSTRACT: The alarming increase of pathogenic bacteria that are resistant to multiple antibiotics is now recognized as a major health issue fuelling demand for new drugs. Bacterial resistance is often caused by molecular changes at the bacterial surface, which alter the nature of specific drug-target interactions. Here, we identify a novel mechanism by which drug-target interactions in resistant bacteria can be enhanced. We examined the surface forces generated by four antibiotics; vancomycin, ristomycin, chloroeremomycin and oritavancin against drug-susceptible and drug-resistant targets on a cantilever and demonstrated significant differences in mechanical response when drug-resistant targets are challenged with different antibiotics although no significant differences were observed when using sus

SUBMITTER: Ndieyira JW 

PROVIDER: S-EPMC5290737 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature