Immune Signature of Enhanced Functional Avidity CD8⁺ T Cells in vivo Induced by Vaccinia Vectored Vaccine.

ABSTRACT: Functional avidity of T cells is a critical determinant for clearing viral infection and eliminating tumor. Understanding how functional avidity is maintained in T cells is imperative for immunotherapy. However, studies systematically characterize T cell with high functional avidity induced in vivo are still lacking. Previously, we and others found vaccinia vectored vaccine (VACV) induced antigen-specific CD8⁺ T cells with relatively high functional avidity to those from DNA vaccine. Herein, we used functional, immune phenotyping and transcriptomic studies to define the immune signature of these CD8⁺ T cells with high functional avidity. Antigen-specific CD8⁺ T cells induced by VACV executed superior in vivo killing activity and displayed a distinct transcr

SUBMITTER: Hu Z 

PROVIDER: S-EPMC5290741 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature