A Genome-Wide Association Study Identifies Genetic Variants Associated with Mathematics Ability.

ABSTRACT: Mathematics ability is a complex cognitive trait with polygenic heritability. Genome-wide association study (GWAS) has been an effective approach to investigate genetic components underlying mathematic ability. Although previous studies reported several candidate genetic variants, none of them exceeded genome-wide significant threshold in general populations. Herein, we performed GWAS in Chinese elementary school students to identify potential genetic variants associated with mathematics ability. The discovery stage included 494 and 504 individuals from two independent cohorts respectively. The replication stage included another cohort of 599 individuals. In total, 28 of 81 candidate SNPs that met validation criteria were further replicated. Combined meta-analysis of three cohorts identifi

SUBMITTER: Chen H 

PROVIDER: S-EPMC5290743 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature