Vibrio cholerae strains with mutations in an atypical type I secretion system accumulate RTX toxin intracellularly.

ABSTRACT: This study shows that the Vibrio cholerae RTX toxin is secreted by a four-component type I secretion system (TISS) encoded by rtxB, rtxD, rtxE, and tolC. ATP-binding site mutations in both RtxB and RtxE blocked secretion, demonstrating that this atypical TISS requires two transport ATPases that may function as a heterodimer.

SUBMITTER: Boardman BK 

PROVIDER: S-EPMC529086 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature