Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease.

ABSTRACT:

Importance

Human episodic memory performance is linked to the function of specific brain regions, including the hippocampus; declines as a result of increasing age; and is markedly disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that primarily affects the hippocampus. Exploring the molecular underpinnings of human episodic memory is key to the understanding of hippocampus-dependent cognitive physiology and pathophysiology.

Objective

To determine whether biologically defined groups of genes are enriched in episodic memory performance across age, memory encoding-related brain activity, and AD.

Design, setting, and participants

In this multicenter collaborative study, which began in August 2008 and is ongoing, gene set enrichment analysi

SUBMITTER: Heck A 

PROVIDER: S-EPMC5291164 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature