Metformin Treatment Does Not Affect Testicular Size in Offspring Born to Mothers with Gestational Diabetes.

ABSTRACT:

Objectives

Studies in rodents suggest that metformin treatment during pregnancy may have harmful effects on testicular development in offspring. Our aim was to determine whether metformin treatment of gestational diabetes mellitus (GDM) affects testicular size in male offspring.

Methods

We compared the testicular size in prepubertal boys born to mothers who participated in a randomized controlled trial (RCT) comparing metformin with insulin in the treatment of GDM. Twenty-five (42.4% of invited) and 27 (52.9% of invited) boys whose mothers had been treated with metformin or insulin, respectively, participated in the study. Testicular size was measured by a ruler, an orchidometer, and by ultrasonography at the age of 33 to 85 months.

Results

The mean age of the boys wa

SUBMITTER: Tertti K 

PROVIDER: S-EPMC5291182 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature