Ontology highlight
ABSTRACT:
SUBMITTER: Richardson TG
PROVIDER: S-EPMC5291201 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Richardson Tom G TG Shihab Hashem A HA Hemani Gibran G Zheng Jie J Hannon Eilis E Mill Jonathan J Carnero-Montoro Elena E Bell Jordana T JT Lyttleton Oliver O McArdle Wendy L WL Ring Susan M SM Rodriguez Santiago S Campbell Colin C Smith George Davey GD Relton Caroline L CL Timpson Nicholas J NJ Gaunt Tom R TR
Human molecular genetics 20160824 19
<h4>Background</h4>Single variant approaches have been successful in identifying DNA methylation quantitative trait loci (mQTL), although as with complex traits they lack the statistical power to identify the effects from rare genetic variants. We have undertaken extensive analyses to identify regions of low frequency and rare variants that are associated with DNA methylation levels.<h4>Methods</h4>We used repeated measurements of DNA methylation from five different life stages in human blood, t ...[more]