Editor's Highlight: CCR2 Regulates Inflammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure.

ABSTRACT: Ozone-induced lung injury is associated with an accumulation of activated macrophages in the lung. Chemokine receptor CCR2 mediates the migration of inflammatory monocytes/macrophages to sites of tissue injury. It is also required for monocyte egress from the bone marrow. In the present studies, we analyzed the role of CCR2 in inflammatory cell trafficking to the lung in response to ozone. Treatment of mice with ozone (0.8 ppm, 3 h) resulted in increases in proinflammatory CCR2⁺ macrophages in the lung at 24 h, as well as proinflammatory CD11b ⁺ Ly6C^Hi and iNOS⁺ macrophages at 24 and 48 h. Mannose receptor⁺ anti-inflammatory macrophages were also observed in the lung 24 and 48 h post-ozone. Loss of CCR2 was associated with reduced numb

SUBMITTER: Francis M 

PROVIDER: S-EPMC5291213 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature