Ontology highlight
ABSTRACT:
SUBMITTER: Gatchalian J
PROVIDER: S-EPMC5291243 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20160325 13
Histone post-translational modifications, and specific combinations they create, mediate a wide range of nuclear events. However, the mechanistic bases for recognition of these combinations have not been elucidated. Here, we characterize crosstalk between H3T3 and H3T6 phosphorylation, occurring in mitosis, and H3K4me3, a mark associated with active transcription. We detail the molecular mechanisms by which H3T3ph/K4me3/T6ph switches mediate activities of H3K4me3-binding proteins, including thos ...[more]