Suggestions to Reduce Clinical Fibromyalgia Pain and Experimentally Induced Pain Produce Parallel Effects on Perceived Pain but Divergent Functional MRI-Based Brain Activity.

ABSTRACT:

Objective

Hypnotic suggestion is an empirically validated form of pain control; however, the underlying mechanism remains unclear.

Methods

Thirteen fibromyalgia patients received suggestions to alter their clinical pain, and 15 healthy controls received suggestions to alter experimental heat pain. Suggestions were delivered before and after hypnotic induction with blood oxygen level-dependent (BOLD) activity measured concurrently.

Results

Across groups, suggestion produced substantial changes in pain report (main effect of suggestion, F2, 312 = 585.8; p < .0001), with marginally larger changes after induction (main effect of induction, F1, 312 = 3.6; p = .060). In patients, BOLD response increased with pain report in regions previously associated with pain, including

SUBMITTER: Derbyshire SW 

PROVIDER: S-EPMC5291284 | biostudies-literature | 2017 Feb/Mar

REPOSITORIES: biostudies-literature