Dynamic Maternal Gradients Control Timing and Shift-Rates for Drosophila Gap Gene Expression.

ABSTRACT: Pattern formation during development is a highly dynamic process. In spite of this, few experimental and modelling approaches take into account the explicit time-dependence of the rules governing regulatory systems. We address this problem by studying dynamic morphogen interpretation by the gap gene network in Drosophila melanogaster. Gap genes are involved in segment determination during early embryogenesis. They are activated by maternal morphogen gradients encoded by bicoid (bcd) and caudal (cad). These gradients decay at the same time-scale as the establishment of the antero-posterior gap gene pattern. We use a reverse-engineering approach, based on data-driven regulatory models called gene circuits, to isolate and characterise the explicitly time-dependent effects of changing morphoge

SUBMITTER: Verd B 

PROVIDER: S-EPMC5291410 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature