Fecal microbiota transplantation in patients with slow-transit constipation: A randomized, clinical trial.

ABSTRACT: Fecal microbiota transplantation has been proposed as a therapeutic approach for chronic constipation. This randomized, controlled trial aimed to compare the effects of conventional treatment alone (control) with additional treatment with FMT (intervention) in patients with slow-transit constipation (STC). Adults with STC were randomized to receive intervention or control treatment. The control group received education, behavioral strategies, and oral laxatives. The intervention group was additionally provided 6 days of FMT. The primary endpoint was the clinical cure rate (proportion of patients achieving a mean of ≥ three complete spontaneous bowel movements [CSBMs] per week]. Secondary outcomes and safety parameters were assessed throughout the study. Sixty patients were randomized to ei

SUBMITTER: Tian H 

PROVIDER: S-EPMC5291446 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature