Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma.

ABSTRACT:

Objective

Androgen deprivation therapy (ADT) increases fracture risk in men with carcinoma of the prostate, but little is known about the fracture risk for different types of ADT. We studied the fracture risk amongst Chinese patients with carcinoma of the prostate prescribed different ADT regimens.

Subjects and methods

This was a single-centered observational study that involved 741 patients with carcinoma of the prostate from January 2001 to December 2011.

Results

After a median follow-up of 5 years, 71.7% of the study cohort received ADT and the incidence rate of fracture was 8.1%. Multivariable Cox regression analysis revealed that use of ADT was significantly associated with risk of incident fracture (Hazard Ratio [HR] 3.60; 95% Confidence Interval [95% CI] 1.41-9

SUBMITTER: Lee CH 

PROVIDER: S-EPMC5291449 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature