Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting.

ABSTRACT: The blood-brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross the BBB, many strategies have been developed: invasive techniques, such as temporary disruption of the BBB or direct intraventricular and intracerebral administration of the drug, as well as noninvasive techniques. Preliminary results, reported in the large number of studies on the potential strategies for brain delivery, are encouraging, but it is far too early to draw any conclusion about the actual use of these therapeutic approaches. Among the most recent, but still pioneering, approaches related to the nasal mucosa properties, the per

SUBMITTER: Marianecci C 

PROVIDER: S-EPMC5291459 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature