A large population-based association study between HLA and KIR genotypes and measles vaccine antibody responses.

ABSTRACT: Human antibody response to measles vaccine is highly variable in the population. Host genes contribute to inter-individual antibody response variation. The killer cell immunoglobulin-like receptors (KIR) are recognized to interact with HLA molecules and possibly influence humoral immune response to viral antigens. To expand on and improve our previous work with HLA genes, and to explore the genetic contribution of KIR genes to the inter-individual variability in measles vaccine-induced antibody responses, we performed a large population-based study in 2,506 healthy immunized subjects (ages 11 to 41 years) to identify HLA and KIR associations with measles vaccine-induced neutralizing antibodies. After correcting for the large number of statistical tests of allele effects on measles-specific

SUBMITTER: Ovsyannikova IG 

PROVIDER: S-EPMC5291460 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature