Predictors of opioid efficacy in patients with chronic pain: A prospective multicenter observational cohort study.

ABSTRACT: Opioids are increasingly used for treatment of chronic pain. However, they are only effective in a subset of patients and have multiple side effects. Thus, studies using biomarkers for response are highly warranted. The current study prospectively examined 63 opioid-naïve patients initiating opioid use for diverse types of chronic pain at five European centers. Quantitative sensory testing, electroencephalography (EEG) recordings, and assessment of pain catastrophizing were performed prior to treatment. The co-primary outcomes were change from baseline in ratings of chronic pain and quality of life after 14 days of opioid treatment. Secondary outcomes included patient's global impression of clinical change and side effects. Logistic regression models adjusted for age and sex were used to i

SUBMITTER: Grosen K 

PROVIDER: S-EPMC5291530 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature