Polymorphisms in the Chlamydia trachomatis cytotoxin locus associated with ocular and genital isolates.

ABSTRACT: Chlamydia trachomatis is a strict human pathogen producing infections that cause medically important chronic inflammatory diseases, such as blinding trachoma and tubal factor infertility. Isolates exist as serotypes that fall into distinct biologic and pathological groups corresponding to differences in infection tissue tropism and invasion properties. Paradoxically, genome sequencing of several diverse strains has revealed a remarkable level of genomic synteny, suggesting that minor genetic differences determine the pathogen host- and tissue-specific infection characteristics. To better understand the genetic basis of chlamydial pathobiologic diversity, we performed comparative DNA-DNA microarray genomic hybridizations with all 15 C. trachomatis serovariants. We found there are few major

SUBMITTER: Carlson JH 

PROVIDER: S-EPMC529170 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature