Polyfunctional and IFN-γ monofunctional human CD4⁺ T cell populations are molecularly distinct.

ABSTRACT: Pathogen-specific polyfunctional T cell responses have been associated with favorable clinical outcomes, but it is not known whether molecular differences exist between polyfunctional and monofunctional cytokine-producing T cells. Here, we report that polyfunctional CD4⁺ T cells induced during Plasmodiumfalciparum (P. falciparum) blood-stage infection in humans have a unique transcriptomic profile compared with IFN-γ monofunctional CD4⁺ T cells and, thus, are molecularly distinct. The 14-gene signature revealed in P. falciparum-reactive polyfunctional T cells is associated with cytokine signaling and lymphocyte chemotaxis, and systems biology analysis identified IL-27 as an upstream regulator of the polyfunctional gene signatu

SUBMITTER: Burel JG 

PROVIDER: S-EPMC5291737 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature