Distinctive Trajectories of Opioid Use Over an Extended Follow-up of Patients in a Multisite Trial on Buprenorphine + Naloxone and Methadone.

ABSTRACT:

Objectives

Uncovering heterogeneities in longitudinal patterns (trajectories) of opioid use among individuals with opioid use disorder can increase our understanding of disease progression and treatment responses to improve care. The present study aims to identify distinctive opioid use trajectories and factors associated with these patterns among participants randomized to treatment with methadone (MET) or buprenorphine + naloxone (BUP).

Methods

Growth mixture modeling was applied to identify distinctive opioid use trajectories among 795 opioid users after their enrollment in a multisite trial during 2006 to 2009, with follow-up interviews conducted during 2011 to 2014.

Results

Four distinctive trajectories were identified based on opioid use over the follow-up perio

SUBMITTER: Hser YI 

PROVIDER: S-EPMC5291756 | biostudies-literature | 2017 Jan/Feb

REPOSITORIES: biostudies-literature