Steroid Hormone Receptor Positive Breast Cancer Patient-Derived Xenografts.

ABSTRACT: The vast majority of breast cancers are positive for estrogen receptor (ER) and depend on estrogens for growth. These tumors are treated with a variety of ER-targeted endocrine therapies, although eventual resistance remains a major clinical problem. Other steroid hormone receptors such as progesterone receptor (PR) and androgen receptor (AR) are emerging as additional prospective targets in breast cancer. The fundamental mechanism of action of these steroid receptors in gene regulation has been defined mainly by several breast cancer cell lines that were established in the late 1970s. More recently, breast cancer patient-derived xenografts (PDX) have been developed by multiple groups at institutions in several countries. These new models capture the large degree of heterogeneity between p

SUBMITTER: Matthews SB 

PROVIDER: S-EPMC5291783 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature