Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway.

ABSTRACT: Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD. Secretory mediators are proposed as one mechanism for stem cell effects because very few stem cells engraft after injection into recipient animals. Recently, nanovesicles that overcome the disadvantages of natural exosomes have been generated artificially from cells. We generated artificial nanovesicles from adipose-derived stem cells (ASCs) using sequential penetration through polycarbonate membranes. ASC-derived artificial nanovesicles displayed a 100 nm-sized spherical shape similar to ASC-derived natural exosomes and expressed both exosomal and stem cell markers. The proliferation rate of lung epithelial cells was increased in cells treated with ASC-derived artificial nanovesicles compared with ce

SUBMITTER: Kim YS 

PROVIDER: S-EPMC5291836 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature