IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis.

ABSTRACT:

Aim

To investigate the association of seven single nucleotide polymorphisms (SNPs) of the IL23R gene with the clinical picture of ulcerative colitis (UC).

Methods

Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23R gene (rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).

Results

Four out of seven analyzed SNP

SUBMITTER: Fischer S 

PROVIDER: S-EPMC5291849 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature