Does Endurance Training Compensate for Neurotrophin Deficiency Following Diabetic Neuropathy?

ABSTRACT:

Background

A lack of neurotrophic support is believed to contribute to the development of diabetic neuropathy. On the other hand, neurotrophins have consistently been shown to increase in the central and peripheral nervous system following exercise, but the effects of exercise intervention on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in diabetic neuropathy are not understood.

Objectives

This experimental study was designed and carried out at the Tarbiat Modares university (TMU) in Tehran, Iran, to investigate the hypothesis that increased activity as endurance training can help to increase the endogenous expression of neurotrophins in diabetic rats.

Methods

This was an experimental study with 2 × 2 factorial plans performed at TMU in Iran.

SUBMITTER: Eslami R 

PROVIDER: S-EPMC5291940 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature