Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis.

ABSTRACT: Microvascular endothelial cells (ECs) display a high degree of phenotypic and functional heterogeneity among different organs. Organ-specific ECs control their tissue microenvironment by angiocrine factors in health and disease. Liver sinusoidal endothelial cells (LSECs) are uniquely differentiated to fulfill important organ-specific functions in development, under homeostatic conditions, and in regeneration and liver pathology. Recently, Bmp2 has been identified by us as an organ-specific angiokine derived from LSECs. To study angiocrine Bmp2 signaling in the liver, we conditionally deleted Bmp2 in LSECs using EC subtype-specific Stab2-Cre mice. Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre;Bmp2^fl/fl (Bmp2^LSECKO) mice caused massive iron over

SUBMITTER: Koch PS 

PROVIDER: S-EPMC5291964 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature