Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction.

ABSTRACT:

Background

The genetic and environmental influences on human personality and behaviour are a complex matter of ongoing debate. Accumulating evidence indicates that short tandem repeats (STRs) in regulatory regions are good candidates to explain heritability not accessed by genome-wide association studies.

Methods

We tested for associations between the genotypes of four selected repeats and 18 traits relating to personality, behaviour, cognitive ability and mental health in a well-studied longitudinal birth cohort (n = 458-589) using one way analysis of variance. The repeats were a highly conserved poly-AC microsatellite in the upstream promoter region of the T-box brain 1 (TBR1) gene and three previously studied STRs in the activating enhancer-binding protein 2-beta (AP2-β)

SUBMITTER: Bagshaw AT 

PROVIDER: S-EPMC5291968 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature