The effects of low tidal ventilation on lung strain correlate with respiratory system compliance.

ABSTRACT:

Background

The effect of alterations in tidal volume on mortality of acute respiratory distress syndrome (ARDS) is determined by respiratory system compliance. We aimed to investigate the effects of different tidal volumes on lung strain in ARDS patients who had various levels of respiratory system compliance.

Methods

Nineteen patients were divided into high (C_high group) and low (C_low group) respiratory system compliance groups based on their respiratory system compliance values. We defined compliance ≥0.6 ml/(cmH₂O/kg) as C_high and compliance <0.6 ml/(cmH₂O/kg) as C_low. End-expiratory lung volumes (EELV) at various tidal volumes were measured by nitrogen wash-in/washout. Lung strain was calculated as the rat

SUBMITTER: Xie J 

PROVIDER: S-EPMC5291981 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature