Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.

ABSTRACT: Compelling clinical, social, and economic reasons exist to innovate in the process of drug discovery for neuropsychiatric disorders. The use of patient-specific, induced pluripotent stem cells (iPSCs) now affords the ability to generate neuronal cell-based models that recapitulate key aspects of human disease. In the context of neuropsychiatric disorders, where access to physiologically active and relevant cell types of the central nervous system for research is extremely limiting, iPSC-derived in vitro culture of human neurons and glial cells is transformative. Potential applications relevant to early stage drug discovery, include support of quantitative biochemistry, functional genomics, proteomics, and perhaps most notably, high-throughput and high-content chemical screening. While many

SUBMITTER: Haggarty SJ 

PROVIDER: S-EPMC5292010 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature