Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future.

ABSTRACT: Neuropsychiatric disorders are common health problems affecting approximately 1% of the population. Twin, adoption, and family studies have displayed a strong genetic component for many of these disorders; however, the underlying pathophysiological mechanisms and neural substrates remain largely unknown. Given the critical need for new diagnostic markers and disease-modifying treatments, expanding the focus of genomic studies of neuropsychiatric disorders to include the role of non-coding RNAs (ncRNAs) is of growing interest. Of known types of ncRNAs, microRNAs (miRNAs) are 20-25-nucleotide, single-stranded, molecules that regulate gene expression through post-transcriptional mechanisms and have the potential to coordinately regulate complex regulatory networks. In this review, we summariz

SUBMITTER: Alural B 

PROVIDER: S-EPMC5292013 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature