Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.

ABSTRACT: The metabolic syndrome (MetS) is a constellation of metabolic disorders that increase the risk of developing several diseases including type 2 diabetes and cardiovascular diseases. Although genome-wide association studies (GWAS) have successfully identified variants associated with individual traits comprising MetS, the genetic basis and pathophysiological mechanisms underlying the clustering of these traits remain unclear. We conducted GWAS of MetS in 1427 Africans from Ghana and Nigeria followed by replication testing and meta-analysis in another continental African sample from Kenya. Further replication testing was performed in an African American sample from the Atherosclerosis Risk in Communities (ARIC) study. We found two African-ancestry specific variants that were significantly ass

SUBMITTER: Tekola-Ayele F 

PROVIDER: S-EPMC5292212 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature