Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins.
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ABSTRACT:
SUBMITTER: Langereis MA
PROVIDER: S-EPMC5292239 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins.
Langereis Martijn A MA Bakkers Mark J G MJ Deng Lingquan L Padler-Karavani Vered V Vervoort Stephin J SJ Hulswit Ruben J G RJ van Vliet Arno L W AL Gerwig Gerrit J GJ de Poot Stefanie A H SA Boot Willemijn W van Ederen Anne Marie AM Heesters Balthasar A BA van der Loos Chris M CM van Kuppeveld Frank J M FJ Yu Hai H Huizinga Eric G EG Chen Xi X Varki Ajit A Kamerling Johannis P JP de Groot Raoul J RJ
Cell reports 20150618 12
Sialic acids (Sias), 9-carbon-backbone sugars, are among the most complex and versatile molecules of life. As terminal residues of glycans on proteins and lipids, Sias are key elements of glycotopes of both cellular and microbial lectins and thus act as important molecular tags in cell recognition and signaling events. Their functions in such interactions can be regulated by post-synthetic modifications, the most common of which is differential Sia-O-acetylation (O-Ac-Sias). The biology of O-Ac- ...[more]
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