Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli.

ABSTRACT: Macrophages are ubiquitous innate immune cells that play a central role in health and disease by adopting distinct phenotypes, which are broadly divided into classical inflammatory responses and alternative responses that promote immune suppression and wound healing. Although macrophages are attractive therapeutic targets, incomplete understanding of this functional choice limits clinical manipulation. While individual stimuli, pathways, and genes involved in macrophage functional responses have been identified, how macrophages evaluate complex in vivo milieus comprising multiple divergent stimuli remains poorly understood. Here, we used combinations of "incoherent" stimuli-those that individually promote distinct macrophage phenotypes-to elucidate how the immunosuppressive, IL-10-driven m

SUBMITTER: Chuang Y 

PROVIDER: S-EPMC5292318 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature