Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis.

ABSTRACT: Mounting evidence indicates that infection with Epstein-Barr virus (EBV) has a major role in the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV-infected B cells by CD8⁺ T cells might cause MS by allowing EBV-infected autoreactive B cells to accumulate in the brain. Here we undertake a comprehensive analysis of the T-cell response to EBV in MS, using flow cytometry and intracellular IFN-γ staining to measure T-cell responses to EBV-infected autologous lymphoblastoid cell lines and pools of human leukocyte antigen (HLA)-class-I-restricted peptides from EBV lytic or latent proteins and cytomegalovirus (CMV), in 95 patients and 56 EBV-seropositive healthy subjects. In 20 HLA-A2⁺ healthy subjects and 20 HLA-A2⁺ patients we also analysed CD

SUBMITTER: Pender MP 

PROVIDER: S-EPMC5292561 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature