The Tumorigenicity of Multipotent Adult Germline Stem Cells Transplanted into the Heart Is Affected by Natural Killer Cells and by Cyclosporine A Independent of Its Immunosuppressive Effects.

ABSTRACT: Transplantation of stem cells represents an upcoming therapy for many degenerative diseases. For clinical use, transplantation of pluripotent stem cell-derived cells should lead to integration of functional grafts without immune rejection or teratoma formation. Our previous studies showed that the risk of teratoma formation is highly influenced by the immune system of the recipients. In this study, we have observed a higher teratoma formation rate when undifferentiated so-called multipotent adult germline stem cells (maGSCs) were transplanted into the heart of T, B, and natural killer (NK) cell-deficient RAG2^-/-γc^-/- mice than in RAG2^-/- mice, which still have NK cells. Notably, in both strains, the teratoma formation rate was significantly reduced by the i

SUBMITTER: Hubscher D 

PROVIDER: S-EPMC5292627 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature