Ghrelin and hormonal markers under exercise training in patients with heart failure with preserved ejection fraction: results from the Ex-DHF pilot study.

ABSTRACT:

Background

Over 50% of patients with symptomatic heart failure (HF) experience HF with preserved ejection fraction (HFpEF). Exercise training (ET) is effective in improving cardiorespiratory fitness and dimensions of quality of life in patients with HFpEF. A systemic pro-inflammatory state induced by comorbidities as the cause of myocardial structural and functional alterations has been proposed in HFpEF. ET modifies myocardial structure and has been related to inflammatory state. We investigated Ghrelin, related adipokines, markers of inflammation, and neuro-hormonal activation in patients undergoing a structured ET vs. usual care are with HFpEF.

Methods and results

Ex-DHF-P was a prospective, controlled, randomized multi-centre trial on structured and supervi

SUBMITTER: Trippel TD 

PROVIDER: S-EPMC5292632 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature