Using age-stratified incidence data to examine the transmission consequences of pertussis vaccination.

ABSTRACT: Pertussis is a highly infectious respiratory disease that has been on the rise in many countries worldwide over the past several years. The drivers of this increase in pertussis incidence remain hotly debated, with a central and long-standing hypothesis that questions the ability of vaccines to eliminate pertussis transmission rather than simply modulate the severity of disease. In this paper, we present age-structured case notification data from all provinces of Thailand between 1981 and 2014, a period during which vaccine uptake rose substantially, permitting an evaluation of the transmission impacts of vaccination. Our analyses demonstrate decreases in incidence across all ages with increased vaccine uptake - an observation that is at odds with pertussis case notification data in a numb

SUBMITTER: Blackwood JC 

PROVIDER: S-EPMC5292824 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature