Genomic analysis reveals major determinants of cis-regulatory variation in Capsella grandiflora.

ABSTRACT: Understanding the causes of cis-regulatory variation is a long-standing aim in evolutionary biology. Although cis-regulatory variation has long been considered important for adaptation, we still have a limited understanding of the selective importance and genomic determinants of standing cis-regulatory variation. To address these questions, we studied the prevalence, genomic determinants, and selective forces shaping cis-regulatory variation in the outcrossing plant Capsella grandiflora We first identified a set of 1,010 genes with common cis-regulatory variation using analyses of allele-specific expression (ASE). Population genomic analyses of whole-genome sequences from 32 individuals showed that genes with common cis-regulatory variation (i) are under weaker purifying selection and (ii)

SUBMITTER: Steige KA 

PROVIDER: S-EPMC5293047 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature