Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish.

ABSTRACT: Regeneration requires cells to regulate proliferation and patterning according to their spatial position. Positional memory is a property that enables regenerating cells to recall spatial information from the uninjured tissue. Positional memory is hypothesized to rely on gradients of molecules, few of which have been identified. Here, we quantified the global abundance of transcripts, proteins, and metabolites along the proximodistal axis of caudal fins of uninjured and regenerating adult zebrafish. Using this approach, we uncovered complex overlapping expression patterns for hundreds of molecules involved in diverse cellular functions, including development, bioelectric signaling, and amino acid and lipid metabolism. Moreover, 32 genes differentially expressed at the RNA level had concomi

SUBMITTER: Rabinowitz JS 

PROVIDER: S-EPMC5293114 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature